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Genetics and Epigenetics Mechanism in the Pathogenesis of Behçet’s Disease

[ Vol. 15 , Issue. 1 ]

Author(s):

Jibran Sualeh Muhammad*, Muhammad Ishaq and Khalid Ahmed   Pages 7 - 13 ( 7 )

Abstract:


Background: Behçet’s Disease (BD) is characterized by numerous systemic manifestations and is known for its ability to affect both, arteries and the veins. However, the etiology of BD is only partially understood, and previous studies have demonstrated a role for genetic and epigenetic factors that contribute to disease pathophysiology. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in activating lymphocyte proliferation, maturation, and differentiation in BD. This article presents a review of the published literature mainly from the last 20 years. The topics of main concern were the role of genetic and epigenetic factors as contributing factors in disease pathophysiology.

Result and Conclusion: The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic” or “epigenetic” to search the PubMed database. All the relevant studies identified were included and are described according to the aforementioned subheadings.

Keywords:

Behçet's disease, genetics, epigenetics, arteries, veins, pathogenesis.

Affiliation:

Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, Department of Internal Medicine, Jinnah Medical College Hospital, Korangi, Karachi, Department of Biological and Biomedical Sciences, the Aga Khan University Hospital, Karachi

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