Submit Manuscript  

Article Details


Immunopathogenesis of Behçet Disease

[ Vol. 16 , Issue. 1 ]

Author(s):

Israel Gañán Nieto* and José Luis Castañer Alabau   Pages 12 - 20 ( 9 )

Abstract:


Background: Behçet’s Disease (BD, OMIM 109650) is a chronic relapsing inflammatory disease of unknown etiology with unpredictable exacerbations and remissions. First described in 1937 by the Turkish dermatologist HulusiBehçet, as a trisympton complex (oral and genital ulcers and uveitis), it is now recognized as a multisystemic disease. The syndrome can manifest in diverse ways and can involve nearly every organ system. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. This article presents a review of the relevant published literature about the immunopathogenesis of BD.

Result: The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic”, “epigenetic”, “immunogenetic” or “immune response” to search the PubMed database. All the relevant studies identified were included.

Keywords:

Behçet's disease, genetics, epigenetics, immunopathogenesis, etiology, pathophysiology.

Affiliation:

Department of Immunology. Hospital Universitario Ramon y Cajal, Ctra. Colmenar Viejo, Km 9,100. C.P. 28034. Madrid, Department of Immunology. Hospital Universitario Ramon y Cajal, Ctra. Colmenar Viejo, Km 9,100. C.P. 28034. Madrid



Read Full-Text article