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Rheumatological Diseases in HIV Infection

Author(s):

Liberato Giardullo*, Ada Corrado, Nicola Maruotti, Cinzia Rotondo and Francesco Paolo Cantatore   Pages 1 - 12 ( 12 )

Abstract:


We performed a review of the available literature in order to summarize the pathogenic and clinical connections between HIV infection and rheumatological syndromes. The increasing life expectancy during human immunodeficiency virus (HIV) infection has led to the observation of many rheumatological manifestations over the years in this type of patients. Although the pathological mechanisms are still not fully understood, several rheumatological diseases have been more commonly observed than in the general population especially after the advent of highly active antiretroviral therapy (HAART) and sometimes clinical and serological findings are influenced by the underlying condition which define a characteristic onset or development of the disease. Autoimmune diseases occur during specific stages of the HIV infection, depending on the underlying pathogenic mechanism being mainly influenced by the CD4+ cells count. Several rheumatological diseases show peculiar clinical manifestations influenced by the underlying HIV infection leading to specific features less commonly observed in healthy population. Conversely to pathological findings, broadly HIV-1-neutralizing antibodies (BnAb) observed in several autoimmune diseases such as SLE, could exert a protective part against HIV infection. It is important to evaluate the onset of autoimmune diseases in HIV patients, in order to start the appropriate treatment to avoid harmful events. More studies are needed to enlighten the trend of autoimmune diseases during HIV infection. Pathogenic mechanisms and clinical manifestations of rheumatological diseases during HIV infection will be discussed in this review.

Keywords:

HIV, AIDS, HAART, autoimmune, rheumatology, arthritis

Affiliation:

Rheumatology Clinic “Mario Carrozzo”, Department of Medical and Surgical Sciences, University of Foggia, “Policlinico Riuniti” Universitary Hospital, Viale Pinto, 1 - 71121 Foggia,, Rheumatology Clinic “Mario Carrozzo”, Department of Medical and Surgical Sciences, University of Foggia, “Policlinico Riuniti” Universitary Hospital, Viale Pinto, 1 - 71121 Foggia,, Rheumatology Clinic “Mario Carrozzo”, Department of Medical and Surgical Sciences, University of Foggia, “Policlinico Riuniti” Universitary Hospital, Viale Pinto, 1 - 71121 Foggia,, Rheumatology Clinic “Mario Carrozzo”, Department of Medical and Surgical Sciences, University of Foggia, “Policlinico Riuniti” Universitary Hospital, Viale Pinto, 1 - 71121 Foggia,, Rheumatology Clinic “Mario Carrozzo”, Department of Medical and Surgical Sciences, University of Foggia, “Policlinico Riuniti” Universitary Hospital, Viale Pinto, 1 - 71121 Foggia



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