Maiko Watanabe and Shogo Banno Pages 119 - 130 ( 12 )
Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms that can cause various diseases, including pulmonary disease (PD). In patients with rheumatoid arthritis (RA), numerous pulmonary manifestations, including bronchiectasis, may develop into Mycobacterium avium-complex (MAC)-PD, which can be lethal in patients who are being treated with a tumor necrosis factor-alpha blocker. However, the bronchiectasis associated with NTM-PD is difficult to distinguish from that associated with RA by radiological imaging alone. In addition, the diagnosis of NTM-PD is often hampered by the ease of NTM contamination. For the serological diagnosis of MAC-PD, the enzyme immunoassay (EIA) kit, Capilia MAC Antibody ELISA®, determines the levels of serum IgA antibody to the glycopeptidolipid core of MAC. Here we describe the efficacy of this EIA kit for diagnosing MAC-PD, and we review the characteristics of NTM and the association between RA patients and NTM infections.
Biologics, bronchiectasis, enzyme immunoassay kit, glycopeptidolipid core antigen, mycobacterium avium complex, nontuberculous mycobacterium infection, serodiagnosis, tumor necrosis factor- α blockers, rheumatoid arthritis
Division of Rheumatology, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467- 8601, Japan.