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Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis and Treatment Considerations

[ Vol. 12 , Issue. 2 ]


Dyveke P. Pratt   Pages 91 - 112 ( 22 )


Restless legs syndrome (RLS) or Willis-Ekbom Disease is a common, but frequently under- recognized and misdiagnosed condition seen in many subspecialty practices including neurology, sleep medicine, primary care and rheumatology. Periodic limb movements are a frequent co-morbid diagnosis in RLS. Despite prior beliefs that the condition was “benign”, it has been demonstrated to have a considerable impact on sufferers quality of life, physically and psychologically, as well as socially. This chapter is meant as a comprehensive review of RLS encompassing epidemiology, pathophysiology, diagnosis, and treatment considerations.


Restless legs syndrome, RLS, willis-ekbom disease, WED, periodic limb movements, PLMs.


Department of Neurology, Faculty of University of Illinois College of Medicine, Peoria, 100 NE Randolph Ave, Peoria, Illinois, USA.

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