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Use of Liposomal Drugs in the Treatment of Rheumatoid Arthritis

[ Vol. 4 , Issue. 1 ]

Author(s):

Dimple Chopra, Monica Gulati, Saranjit Singh, Sanjiv Duggal and Rajiv Kumar   Pages 63 - 70 ( 8 )

Abstract:


Rheumatoid arthritis is an autoimmune disease that results in joint deformity and disability. Conventional nonsteroidal anti-inflammatory drugs (NSAIDs), steroids and disease modifying antirheumatic drugs (DMARDs) are used for its treatment. Unconventional therapies, like enzyme oligodeoxy nucleotides, boron neutron capture therapy & radioisotopes are also being tried. The use of all these drugs is limited by a number of adverse effects. These side effects have been overcome to a large extent by the use of liposomes as delivery systems. This review presents rationale for the use of liposomes for the treatment of arthritis. Systemic as well as intra-articular delivery of liposome encapsulated anti-arthritic drugs is discussed. Success and limitations of this approach are also discussed by taking examples of different drug classes.

Keywords:

Arthritis, liposomes, DMARDs, NSAIDs, corticosteroids, intra-articular

Affiliation:

Department of Pharmaceutical Sciences, Punjabi University, Patiala, 147 002, India.



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